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Optic Nerve Formula®

Optic Nerve Formula®

Nutrition Support for Optic Nerve Health  |  Clinically Tested

Doctor Recommended

Optic Nerve Formula®

Nutrition Support for Optic Nerve Health  |  Clinically Tested

This specialized nutritional formulation helps to support optic nerve health with a blend of antioxidants such as Ginkgo biloba, bilberry and grapeseed extracts, plus alpha lipoic acid, omega fatty acids and other key nutrients. These ingredients work to boost antioxidant levels, help support healthy nerve function, and to help maintain normal ocular circulation.
30 day supply: 1 bottle (120 capsules)
 

PRICE: $49.95

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Highlights

 Optic Nerve Formula Highlights

  • Clinically tested formula (Acta Ophthalmologica, 2017) offers targeted support for optic nerve health.
  • Provides Ginkgo biloba to support ocular blood flow, as well as select B vitamins, magnesium, taurine, and flavonoids from bilberry and grapeseed extracts to promote normal vascular function.
  • Delivers eye-healthy omega-3 fatty acids and key antioxidants including alpha-lipoic acid, vitamins C, E, B6, B12 and folate.
  • Provides CoQ10 to support mitochondrial function
  • Made from premium ingredients and manufactured according to the highest quality standards.
  • Recommended dose: four softgels daily (two softgels, taken twice daily).

Ingredients/Use


Suggested Use: Take a total of four capsules daily, with meals (two capsules taken orally, twice daily).

Note: Contains Ginkgo biloba, which may affect platelet aggregation. If you are taking anticoagulant or antiplatelet medication, ask your physician. Pregnant or lactating women or individuals with known medical conditions should consult their physician before using.

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Science


ScienceBased Health (SBH) continually evaluates emerging scientific evidence and SBH products reflect the most current science available. Select a category below to view science information for this product:

Summaries of Key Research Studies
  • Research Summaries - Optic Nerve Formula
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Monograph (scientific rationale)
  • Optic Nerve Formula Monograph
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FAQ Sheet / Selected Science FAQs
  • Optic Nerve Formula_FAQ Sheet
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Rationale for Key Ingredients

Ginkgo biloba Extract (120 mg)
Ginkgo biloba is a botanical source of protective flavonoids and compounds that reduce the clumping of blood platelets. In experimental studies, Ginkgo biloba scavenges nitric oxide radicals implicated in nerve cell damage, and prevents neurotoxicity from excess glutamate. In preliminary clinical trials, Ginkgo biloba has been shown to increase ocular blood flow in healthy people, and to improve visual field in those with normal IOP (the visual field is the area visible when the eyes are stationary). Optic Nerve Formula® provides a level of Ginkgo biloba consistent with these clinical findings.

Omega-3 Fatty Acids: DHA (100 mg), EPA (20 mg)
DHA, an omega-3 fatty acid found in fish, is a primary component of retinal photoreceptors and of the myelin sheath that surrounds nerve fibers in the eye. In lab studies, DHA protects retinal nerve cells during oxidative stress. In patients whose IOP is under control, DHA has been reported to improve contrast sensitivity (the ability to distinguish between an object and its background). DHA is also associated with better macular health). The amount of DHA in Optic Nerve Formula® doubles the typical dietary intake of this important fatty acid. The formula provides 1,080 mg of total omega fatty acids from fish and flaxseed oils.

Folic acid (800 mcg), B12 (300 mcg), B6 (10 mg)
This trio of B vitamins helps maintain healthy blood levels of homocysteine, a compound that, in excess, can damage blood lipids and blood vessels, and promote clotting. Elevated homocysteine has been found to raise the risk of certain forms of glaucoma, as well as cardiovascular disease and neurodegenerative diseases like Alzheimer’s. Evidence suggests that those with vascular disease have an increased risk of glaucoma progression. Levels of B12, needed to form the myelin sheath surrounding optic nerve fibers, are often low in the elderly. Optic Nerve Formula® provides high potency B12 in a highly bioavailable form. The levels of folic acid and B6 in this formula are consistent with those clinically shown to reduce elevated homocysteine

Magnesium (240 mg)
Magnesium is important for maintaining normal vascular tone. In normal tension glaucoma, chronic migraine patients are at risk for faster progression of the disease. In these patients, nerve damage may be related to vasospasm (spasms of vessels) and, thus, decreased blood supply to the optic nerve. Low magnesium levels may be a factor in migraine, and supplementation has been reported to be of clinical benefit. A preliminary report also suggests magnesium is beneficial in glaucoma patients with either elevated or normal eye pressure as measured by visual field. Optic Nerve Formula® provides concentrated and well tolerated sources of magnesium at levels consistent with clinical findings.

Vitamins C (250 mg) and E (30 IU)
Concentrated in the eye’s aqueous humor and in nerve cells, vitamin C helps protect against oxidative stress. Experimentally, vitamin C stimulates production of hyaluronic acid – an important component of the spongy trabecular network that drains fluid from the eye. Low levels of hyaluronic acid have been detected in those with glaucoma. Vitamin E helps protect the fatty acids in cell membranes from oxidative damage. The level of vitamin C in Optic Nerve Formula® reflects the amount generally found to saturate the eye’s aqueous humor. Vitamin E is provided as natural mixed tocopherols, a full spectrum vitamin E including alpha and gamma forms.

Alpha Lipoic Acid (200 mg), Taurine (750 mg) and N-acetylcysteine
Produced in the body, alpha lipoic acid is involved in the production of metabolic energy. Supplemental alpha lipoic has been shown to cross the blood-brain barrier, and to act as a free radical scavenging antioxidant. Experimentally, this antioxidant has been shown to protect nerve cells from glutamate toxicity and nerve tissue from oxidative damage. Clinically, it has been reported to support visual function in those treated with IOP-lowering therapy. Optic Nerve Formula® delivers levels of alpha lipoic acid consistent with clinical findings.

Taurine is an amino acid concentrated in the eye, and found in the optic nerve. that may help counter excess levels of nerve-damaging glutamate in the body. An acute dose of taurine has been clinically shown to promote blood flow under conditions of oxidative stress by restoring the ability of vessels to dilate. Optic Nerve Formula® provides taurine to support normal endothelial function.

NAC, within the cell, provides a key amino acid to produce an ocular defense enzyme called glutathione. Lower levels of glutathione have been associated with late stage glaucoma. In experimental studies, glutathione protects against potentially damaging nitric oxide radicals. An acute dose of NAC is reported to support glutathione levels in healthy women. Optic Nerve Formula® contains NAC at a level that helps ensure adequate glutathione production by the body.

Bilberry extract (100 mg), Grapeseed Extract (50 mg), Quercetin (50 mg)
Flavonoids are plant pigments that, while structurally similar, often function in different ways. Optic Nerve Formula® contributes a significant level of flavonoids from a variety of plant sources. Experimental studies have found that one or more of these antioxidant flavonoids protects retinal cells, recycles vitamin E, counters vasoconstriction, supports capillary integrity, and regulates excess nitric oxide radicals. Large scale population health studies have found clear associations between dietary flavonoids (especially quercetin) and lower risk of mortality from coronary heart disease and stroke. Flavonoids have also been shown to significantly improve antioxidant enzyme activity in healthy individuals.

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References
  1. Brubaker RF. Delayed functional loss in glaucoma. Am J Opththalmol 121: 473-483, 1996.
  2. Weinrab RN and Levin LA. Is neuroprotection a viable therapy for glaucoma. Arch Ophthalmol 117: 1540-1544, 1999.
  3. Schwartz M. Neuroprotection as a treatment for glaucoma. Eur J Ophthalmol Suppl 3: S27-41, 2003 .
  4. Chen JZ, et al. A new clue to glaucoma pathogenesis. Am J Med 114: 697-698, 2003.
  5. Richer S. Review: nutritional influences on eye health. Optometry 71: 657-666, 2000.
  6. Head K. Review. Natural therapies for ocular disorders: cataracts and glaucoma. Altern Med Rev 6: 141-166, 2001.
  7. Zhu L, et al. Antagonistic effects of extract from leaves of ginkgo biloba on glutamate neurotoxicity. Zhongguo Yao Li XZue Bao 18: 344-347, 1997.
  8. Lugasi A, et al. Additional information to the in vitro antioxidant activity of Ginkgo biloba L. Phytother Res 13: 160-162, 1999.
  9. Chung HS, et al. Ginkgo biloba extract increases ocular blood flow velocity. J Ocul Pharmacol Ther 15: 233-240, 1999.
  10. Quaranta L, et al. Effect of Ginkgo biloba on preexisting visual field damage in normal tension glaucoma. Ophthamol 110: 359-62, 2003.
  11. Cellini M, et al. Fatty acid use in glaucomatous optic neuropathy treatment. Acta Ophthalmol Scand Suppl 227: 41-42, 1998.
  12. Cho E, et al. Prospective study of dietary fat and the risk of age-related macular degeneration. Am J Clin Nutr 73: 209-218, 2001.
  13. Anderson DR. Review: Collaborative normal tension glaucoma study. Curr Opin Ophthalmol 14: 86-90, 2003.
  14. Peikert A, et al. Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center placebo-controlled and double-blind randomized study. Cephalalgia 16: 257-263, 1996.
  15. Drance S, et al. Risk factors for progression of visual field abnormalities in normal-tension glaucoma. Am J Ophthalmol 131: 699-708, 2001.
  16. Knepper PA, et al. Glycosaminoglycan stratification of the juxtacanalicular tissue in normal and primary open-angle glaucoma. Invest Ophthalmol 37: 2414- 2425, 1996.
  17. Ziegler D, et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A 7 month multicenter randomized controlled trial. Diabetes Care 22: 1296-1301, 1999.
  18. Fennessy FM, et al. Taurine and vitamin C modify monocyte and endothelial dysfunction in young smokers. Circulation 107: 2003.
  19. Roes EV, et al. Effects of oral N-acetylcysteine on plasma homocysteine and whole blood glutathione levels in healthy, non-pregnant women. Clin Chem Lab Med 40: 496-498, 2002.
  20. Hertog MG, Feskens EJ, Hollman PC, Katan MB, Kromhout D. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 342: 1007-1011, 1993.
  21. Hwa-Young K, et al. Effects of phenol-depleted and phenol-rich diets on blood markers of oxidative stress, and urinary excretion of quercetin and kaempferol in healthy volunteers. J Am Coll Nutr 22: 217-233, 2003.
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FAQs



Following are some frequently asked questions about this product. Click on a question to view each answer.
 

FAQs
  • What is Optic Nerve Formula®?
  • Optic Nerve Formula is a specialized oral formulation designed to help protect the optic nerve. It provides targeted support in four softgels daily.

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  • What Does This Formula Target?
  • Optic Nerve Formula delivers nutrients that help:
      • Quench free radicals
      • Enhance ocular circulation
      • Promote normal vascular function.
      • Inhibit compounds that damage nerve cells

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  • Who Might Benefit from Optic Nerve Formula?
  • The health of the optic nerve can be compromised in many conditions, such as ischemic neuropathies and glaucoma. Optic Nerve Formula augments ocular defenses during oxidative stress, and provides nutritional support for:
      • Those with optic nerve disorders
      • Those wanting to help protect optic nerve health

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  • Can This Formula Be Used by Those with Elevated or Normal IOP?
  • Optic Nerve Formula can be appropriately used when intra-ocular pressure (IOP) is elevated as well as when IOP falls within the normal range. Glaucoma is now viewed as a neurodegenerative disease that occurs over a wide range of IOP. Oxidative stress plays a role in damage to neurons and cells in the trabecular meshwork, and ocular defenses may be compromised in glaucoma. Since glaucoma can progress despite treatment, Optic Nerve Formula can complement IOP lowering treatments for those with elevated or normal IOP.

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  • Are There Any Cautionary Notes?
  • The ingredient Ginkgo biloba may affect platelet aggregation. Thus, the use of Optic Nerve Formula along with anti-coagulation or anti-platelet medications could raise the risk of increased bleeding. This can be monitored by occasionally measuring Pro-thrombin Time and International Normalized Ratio (PT/INR) to evaluate the ability of the blood to clot properly. The formula is not intended for pregnant or lactating women. Individuals with an existing medical condition should consult their physician before using.

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Home  >  Optic Nerve Support
This specialized nutritional formulation helps to support optic nerve health with a blend of antioxidants such as Ginkgo biloba, bilberry and grapeseed extracts, plus alpha lipoic acid, omega fatty acids and other key nutrients. These ingredients work to boost antioxidant levels, help support healthy nerve function, and to help maintain normal ocular circulation.

30 day supply: 120 softgels

Innovative Nutraceuticals for Eye Health

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