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MacularProtect Complete®

MacularProtect Complete®

AREDS2 Support for Macular & Whole Body Health

Doctor Recommended

MacularProtect Complete®

AREDS2 Support for Macular & Whole Body Health

MacularProtect Complete is a convenient, all-in-one formula offering powerful support for macular & whole body health. It delivers over 30-key nutrients at levels found to promote healthy vision in the AREDS and AREDS 2 clinical trials, including 10 mg of lutein and 2 mg of zeaxanthin. MacularProtect Complete features a wide array of cell-protecting nutrients such as turmeric and bilberry extracts, trans-resveratrol, alpha lipoic acid and more.
30 day supply: 1 bottle (120 capsules)                VIEW DRINK MIX  MacularProtect Complete  Drink Mix

 

PRICE: $39.95

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Highlights
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Highlights

Available options for this product:

Drink Mix  Try the MacularProtect Complete Drink Mix!
MacularProtect Complete Highlights
  • Convenient, all-in-one formulation provides powerful support for macular and whole body health. No additional multinutrient is needed.
  • Appropriate for individuals concerned about maintaining visual and overall body health.
  • Contains vitamins C and E, zinc, copper, lutein and zeaxanthin at levels found to support eye health in the AREDS and AREDS 2 clinical trials.
  • Provides 10 mg of bioavailable FloraGLO® lutein and 2 mg of zeaxanthin (FloraGLO and OptiSharp).
  • Features comprehensive multinutrient support with over 30 additional key nutrients, including a diverse array of bioflavonoids, antioxidants and other essential vitamins and minerals to protect the health of the whole body.
  • Made from premium ingredients and manufactured according to the highest quality standards.

  • Recommended dose: four capsules per day (two capsules taken orally, twice daily with meals).
  •  Read about the scientific rationale behind this product in the MacularProtect Complete monograph.
  •   View the MacularProtect Complete brochure.

Ingredients/Use



Suggested Use: take a total of four capsules daily, with meals (two capsules taken orally, twice daily).

Note: pregnant or lactating women or individuals with medical conditions should consult a physician before using.

Note: MacularProtect Complete contains 80 mg of zinc, a level that was found to support eye health in the AREDS clinical trial. It is important to check with your physician prior to taking this product to ensure that this level of zinc is appropriate for you.

View product shelf life information

Science



ScienceBased Health (SBH) continually evaluates emerging scientific evidence and SBH products reflect the most current science available. Select a category below to view science information for this product:

  • Related Information: Read an exclusive interview with Allen Taylor, PhD, World-Renowned Vision Researcher on Nutrition, Cataract and AMD
  • Related Information: Read / listen to an interview with Paul Bernstein, MD, PhD on the Role of Lutein & zeaxanthin in Macular Health

Summaries of Key Research Studies
  • Research Summaries - AREDS
  • Research Summaries - Multinutrients
  • Research Summaries - Lutein
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Monograph (scientific rationale)
  • MacularProtect Complete AREDS2 Monograph
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Rationale for Key Ingredients

Vitamin A (500 IU)

Vitamin A is essential for protecting night vision and is vital for corneal health. It also works with zinc and the amino acid taurine to support function of eye structures such as retinal photoreceptors. The formula contributes a conservative level (as retinyl palmitate) to ensure adequate body stores.

Vitamin C (750 mg)

Vitamin C is a water-soluble antioxidant that is concentrated in ocular tissues where it deactivates free radicals. Free radicals are the highly reactive compounds produced through the body’s use of oxygen and generated by outside sources such as UV light. Oxidative damage to the retina is believed to be a risk factor for macular degeneration. Vitamin C also aids in the recycling of other antioxidants such as vitamin E. Evidence indicates that vitamin C and E requirements are higher in smokers – a group at higher risk for AMD. MacularProtect Complete AREDS2 supplies the form and level of vitamin C used in AREDS, plus an additional 250 mg.

Vitamin E (400 IU)

Fat-soluble vitamin E is the major chain-breaking antioxidant present in retinal and macular membranes. As a first line of defense against fatty acid peroxidation, vitamin E helps protect cell membranes against free radical attack. MacularProtect Complete AREDS2 uses natural source vitamin E rather than synthetic, as research shows that natural source offers superior bioavailability and is better retained in tissues. It also delivers broad spectrum vitamin E from alpha to gamma tocopherol, that together play a health-protective role. The formula includes 400 IU of vitamin E, the level used in AREDS.

Zinc (80 mg)

Zinc is an essential mineral that is selectively concentrated in the eye. It is found in the retina, choroid, ciliary body, iris, optic nerve, sclera, cornea, and lens. Within these ocular structures zinc is believed to interact with vitamin A and taurine to modify photoreceptor membranes, to help regulate the light-rhodopsin reaction, to influence nerve transmission, and to serve as an antioxidant. MacularProtect Complete AREDS2 provides the same form and level provided to AREDS participants.

Copper (2 mg)

The mineral copper is necessary for function of a key antioxidant enzyme. It is also needed to produce connective tissue, nerve sheaths, skin pigment, and for the proper utilization of iron. Since high levels of zinc compete with copper for absorption, copper is included in MacularProtect Complete AREDS2 to help ensure adequate levels of this essential mineral. The formula's copper level represents 100% of the Daily Value and is the form and amount use in the AREDS trial.

Lutein, FloraGLO® (10 mg) and Zeaxanthin (2 mg)

Lutein and zeaxanthin are two similarly structured carotenoids found in green leafy vegetables like spinach, kale and mustard greens. These carotenoids make up the macular pigment of the retina, the tissue with the highest concentration of lutein and zeaxanthin in the body. As part of the macular pigment, zeaxanthin and lutein filter blue (visible) light that can cause photo-oxidative stress.

Intervention studies indicate supplementation with these carotenoids can favorably modify the pigment density of the macula. AREDS2 reported an 18% reduction in progression to advanced AMD in participants who received the AREDS supplement with lutein/zeaxanthin in place of beta-carotene (compared to those taking the original AREDS supplement with beta-carotene). For participants receiving lutein/zeaxanthin supplements, a 26% reduced risk of progression was seen in those consuming the least lutein/zeaxanthin at the study’s start, compared to those consuming the most. The average daily intake of these two carotenoids among Americans 50 and older is less than 2 mg – far lower than the 12 mg tested in AREDS2. The formula's lutein/zeaxanthin level reflects that used in AREDS2.

Other Essential Nutrients for Eye and Whole Body Health

MacularProtect Complete AREDS2 provides robust levels of key B-vitamins, particularly vitamin B12, which can be difficult to absorb by those over 50, as well as vitamin B6 and folate for artery and colon health. A large clinical trial found this B vitamin trio reduced AMD risk in women with or at risk for heart disease, and higher vitamin B12 and folic acid blood levels have been linked to lower AMD risk in an observational study. These B-vitamins may also support cognitive function.

Plant compounds with antioxidant activity such as the flavonoids contribute to the health benefits of eating five or more fruit and vegetable servings daily. Regular intake of berry flavonoids, for example, is linked to better odds of retaining heart health. MacularProtect Complete AREDS2 contains a unique array of protective flavonoids from diverse sources: bilberry, citrus, grape seed, Ginkgo biloba, turmeric and quercetin, which is found in many fruits and vegetables.

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References
  1. AREDS Report No. 8. A randomized, placebo-controlled clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss. Arch Ophthalmol 119: 1417-36, 2001.
  2. The AREDS2 Research Group. Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration. JAMA Ophthalmol 309:2005-15, 2013.
  3. Sebastian R, et al. Older adults who use vitamin/mineral supplements differ from nonuser in nutrient intake adequacy and dietary attitudes. J Am Dietetic Assoc 107:1322-32, 2007.
  4. Gaziano JM, et al. Multivitamins in the prevention of cancer in men—The Physicians’ Health Study II randomized controlled trial. JAMA, 308:1871-80, 2012.
  5. AREDS Research Group. Centrum use and progression of age-related cataract in AREDS. Ophthalmol 113:1264-70, 2006.
  6. Harris E, et al. Effects of a multivitamin, mineral and herbal supplement on cognition and blood biomarkers in older men: a randomised, placebo-controlled trial. Hum Psychopharmacol 27:370-7, 2012.
  7. Grima NA, et al. The effects of multivitamins on cognitive performance: a systematic review and meta-analysis. J Alzheimers Dis 29:561-9, 2012.
  8. Brondum-Jacobsen P, et al. 25-hydroxyvitamin D and symptomatic ischemic stroke: an original study and meta-analysis. Ann Neurol 73:38-47, 2013.
  9. Prentice RL, et al. Health risks and benefits from calcium and vitamin D supplementation: Women's Health Initiative clinical trial and cohort study. Osteoporos Int 24:567-80, 2013.
  10. Klettner A, et al. Review: Cellular and molecular mechanisms of age-related macular degeneration: From impaired autophagy to neovascularization. Int J Biochem Cell Biol 45:1457-67, 2013.
  11. Bruno RS, et al. Alpha tocopherol disappearance is faster in cigarette smokers and is inversely related to their ascorbic acid status. Am J Clin Nutr 81: 95-103, 2005.
  12. Kelly G. (Review) The interaction of cigarette smoking and antioxidants Part III: Ascorbic acid. Alt Med Rev 8: 43-54, 2003.
  13. Burton GW, et al. Human plasma and tissue alpha-tocopherol concentrations in response to supplementation with deuterated natural and synthetic vitamin E. Am J Clin Nutr 67: 669-84, 1998.
  14. Mah E, et al. Supplementation of a ?-tocopherol-rich mixture of tocopherols in healthy men protects against vascular endothelial dysfunction induced by postprandial hyperglycemia. J Nutr Biochem 24:196-203, 2013.
  15. Grahn BH, et al. Review: Zinc and the eye. J Am Coll Nutr 20: 106-18, 2001.
  16. Weigert G, et al. Effects of lutein supplementation on macular pigment optical density and visual acuity in patients with age-related macular degeneration. Invest Ophthalmol Vis Sci 52:8174-78, 2011.
  17. Dawczynski J, et al. Long term effects of lutein, zeaxanthin and omega-3-LCPUFAs supplementation on optical density of macular pigment in AMD patients: the LUTEGA study. Graefes Arch Clin Exp Ophthalmol, Epub May 22, 2013.
  18. Rasmussen HM and Johnson EJ. Nutrients for the aging eye. Clin Inter Aging 8:741-48, 2013.
  19. Christen WG, et al. Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women: the Women's Antioxidant and Folic Acid Cardiovascular Study. Arch Intern Med 169: 335-41, 2009.
  20. Gopinath B, et al. Homocysteine, folate, vitamin B-12, and 10-y incidence of age-related macular degeneration. Am J Clin Nutr 98:129-35, 2013.
  21. de Jager CA, et al. Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial. Int J Geriatr Psychiatry. 27:592-600, 2012.
  22. Cassidy A, et al. High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women. Circulation 127:188-96, 2013.
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FAQs



Following are some frequently asked questions about this product. Click on a question to view each answer.
 

FAQs
  • Does this product meet National Eye Institute recommendations for a macular supplement based on the AREDS and AREDS2 clinical trials?
  • MacularProtect Complete AREDS2 includes the nutrients and levels recommended by the National Eye Institute, based on the findings from the AREDS2 clinical trial. In particular, this product includes 10 mg of lutein and 2 mg of zeaxanthin, plus robust levels of B-vitamins found to support macular health in additional NEI-sponsored research. Providing over 30 key nutrients, MacularProtect Complete AREDS2 also includes a complete multinutrient component, plus a wide array of cell-protecting nutrients.

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  • What were the findings of the AREDS and AREDS2 clinical trials?
  • The findings for the Age-Related Disease Study (AREDS) were released in October, 2001. The AREDS clinical trial has been heralded by doctors and nutrition experts as the most significant clinical trial on nutrition and age-related macular degeneration (AMD) ever. Findings of the 6 ½ year AREDS clinical trial, demonstrated a statistically significant reduction in the rate of progression of AMD in 3,640 patients taking a supplement containing vitamins, antioxidants and zinc.

    The AREDS2 clinical trial, released in May, 2013, tested several variations of the original AREDS supplement, in addition to omega-3 fatty acids from fish oil, and lutein and zeaxanthin. Read more about the findings here. Based on the findings from AREDS2, the National Eye Institute now recommends a beta-carotene free formula (with lutein and zeaxanthin), such as MacularProtect Complete.

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  • I've heard that people with certain genetic profiles should use a zinc-free macular supplement - is that really true?
  • Some analyses of genetic data from the AREDS clinical trial have questioned the role of zinc for those with certain genetic risk factors for age-related macular degeneration. However, these findings are not supported by independent analyses of AREDS data, which found health benefits from zinc across all genetic profiles examined. Further, 3 independent biostatistics teams at top medical centers have assessed this question, and have concluded that there is no evidence for zinc increasing risk of AMD progression for those with high risk or other specific genetic profiles. Based on the totality of evidence, the American Academy of Ophthalmology has recommended against genetic testing by ophthalmologists for AMD and other complex eye diseases. SBH has consulted with top experts in the fields of genetics and nutrition and continues to monitor the evidence on this issue.

    Since studies to date on this topic have relied on very limited data, and since the influence of zinc on AMD genetic risk has never been tested in a gold standard clinical trial, more research is clearly needed. The National Eye Institute continues to recommend a macular formula that includes 80 mg of zinc for those with intermediate to advanced AMD. SBH will continue to monitor the research on this topic. To view SBH's detailed response to this issue, click here.

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  • What's the difference between MacularProtect Complete and MacularProtect?
  • In addition to the nutrients studied in the AREDS and AREDS2 clinical trials, MacularProtect Complete contains a complete multivitamin / multinutrient for overall body health. No additional multinutrient is needed.

    MacularProtect is a stand-alone product based on AREDS and AREDS2 - but does not provide a multinutrient component.

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  • Should I take a multivitamin in addition to MacularProtect Complete AREDS2?
  • An additional multivitamin should not be used with MacularProtect Complete. MacularProtect Complete is a powerful formulation to protect macular health and also includes a complete multivitamin. The multivitamin component of MacularProtect Complete AREDS2 is robust, providing meaningful quantities of key nutrients at higher levels than are found in most daily multivitamins such as One-A-Day® or Centrum® Silver.

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  • I have a family history of macular health issues, but no immediate eye health concerns - should I use this product?
  • In this case, it would generally be recommended to take a multivitamin instead, such as OcularProtect, which provides robust support for eye and whole body health.

    - Close

 >View More FAQs

Comparison



MacularProtect-Complete AREDS2 is a convenient, all-in-one nutritional formulation that includes the nutrients at levels studied in the AREDS and AREDS2 clinical trials plus a complete multinutrient for whole body health.

MacularProtect-Complete AREDS2 was created in response to doctor concern that patients combining a potent AREDS formula with a separate multivitamin may be exceeding safe levels of certain nutrients, such as zinc. MacularProtect-Complete AREDS2 is carefully formulated to provide complete support for macular and whole body health while ensuring proper nutrient levels. It is also a convenient alternative to having to manage multiple nutritional products.
 

  • View a comparison chart of this product and competing macular products


Testimonials


 
 

"Recent studies have validated the importance of nutraceuticals in the prevention and treatment of various eye conditions. It is important that patients select a quality product that provides optimal levels of key nutrients that have scientifically been shown to protect our eye health. MacularProtect Complete delivers the key nutrients found to protect macular health in the National Eye Institute's AREDS research and also includes a comprehensive multivitamin that provides maximum support for overall body health. This all-in-one product is a convenient solution to the confusion and safety issues that both clinicians and patients face when trying to combine various products to achieve this level of coverage."*

- James Thimons, OD, FAAO
Executive Director, Ophthalmic Consultants of Connecticut
Clinical Professor, New England College of Optometry, Fairfield, CT


"I began taking Macular Protect Complete(-S) about a year ago. I had just been diagnosed with macular degeneration and wanted to do whatever I could to at least slow down the process and protect my eyesight. The retinologist recommended this product to me and I have taken it faithfully since then. I feel it has been a big help as my eyesight seems to be about the same as it was a year ago. In the past, my eyesight was getting a little worse every year.

Thank you for making such a wonderful product!"*

- B. Lessard,
Montclair, CA


"I have used Macular Protect Complete regularly for several years as recommended by my ophthalmologist. I had been undergoing frequent prescription changes for several years. I replaced my regular daily vitamin supplement with Macular Protect Complete and my eyeglass prescription has now been stable for a couple of years. "*

K. Ellis,
Saint Joseph, IL


"I began taking MacularProtectComplete more than four years ago at the recommendation of my ophthalmologist. In that period of time, there has been no appreciable change in my vision. That's not bad for an 89-year old!"*

H. Neidig,
Lebanon, PA

 

 

*Results may vary from person to person

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MacularProtect Complete®
Drink Mix
AREDS2 Support for Macular & Whole Body Health
Based on AREDS, AREDS2, and other Advanced Research
Price: $42.95
Home  >  Macular Health / AREDS
MacularProtect Complete is a convenient, all-in-one formula offering powerful support for macular & whole body health. It delivers over 30-key nutrients at levels found to promote healthy vision in the AREDS and AREDS 2 clinical trials, including 10 mg of lutein and 2 mg of zeaxanthin. MacularProtect Complete features a wide array of cell-protecting nutrients such as turmeric and bilberry extracts, trans-resveratrol, alpha lipoic acid and more.

30 day supply: 120 capsules                VIEW DRINK MIX  MacularProtect Complete Drink Mix

Innovative Nutraceuticals for Eye Health

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